This reader training module supports interpretation skill development of ¹⁸F-FET-PET. Through case study reviews, Dr. Veronesi shares his clinical expertise including anatomy review, ¹⁸F-FET PET reading methodology, comparative modality analysis and tips of how to approach challenging cases. The overall goal of this module is to assist the reader to confidently prepare a report that supports the referring physician(s) when ¹⁸F-FET-PET scanning is introduced into the patient’s journey.

Special attention is given to advanced imaging techniques and their limitations in differentiating tumor recurrence from treatment-related changes. In this context, ¹⁸F-FET PET is highlighted as a critical modality that helps overcome these challenges by providing complementary metabolic information, improving diagnostic confidence and guiding clinical decision-making.

Teaching Points

• Gain clinical experience with ¹⁸F-FET PET and its role across the patient’s clinical journey.
• Identify the independence of ¹⁸F-FET PET signal from blood–brain barrier integrity.
• Appreciate the ability of ¹⁸F-FET PET to overcome the limitations and challenges associated with standard care of imaging.
• Employ ¹⁸F-FET PET in combination with advanced MRI techniques such as perfusion, diffusion, and spectroscopy.
• Improve ¹⁸F-FET PET interpretation to include lesion size, enhancing and non-enhancing tumor regions form impactful outcomes in patient management.

Upon completion of Module 3, the participant is invited to visit Module 4 titled ^"18F-FET-PET Interpretation Skill Development", offering an individual case review opportunity to ‘apply the knowledge’ learned in Module 3.

Note: Test Your Knowledge” competency measurements in the form of quiz questions, will be displayed throughout the module. Upon completion of this Module, a post-test will be offered to provide a Statement of Participation.

Meet the Faculty

Michael Veronesi, MD, PhD
Associate Professor of Radiology
University of Wisconsin

Dr. Veronesi is a physician scientist and neuroradiologist who completed a radiology residency from 2012-2016 and neuroradiology fellowship from 2016-2017 at the University of Chicago Medical Center. He was an assistant professor in neuroradiology at the Indiana University School of Medicine from 2017-2023 before joining the University of Wisconsin Department of Radiology as an associate professor in 2023.

Dr. Veronesi is the Director of Neuro-Oncological Imaging at the University of Wisconsin School of Medicine and Public Health within the Department of Radiology, which is tasked with improving the detection of brain malignancies using advanced multi-modality neuroimaging, including hybrid brain PET/MRI, in the clinical care of patients. Other goals of the program are to facilitate preclinical and clinical research initiatives across various multidisciplinary neurological subspecialties, including quantitative MR imaging, PET radiotracers, targeted therapies, and theranostics agents. This work spans the full spectrum from bench to bedside.

This reader training module offers a foundational understanding of the clinical applications of ¹⁸F-FET-PET. Dr. Oberheim Bush, an experienced Neuro-Oncologist in the field of gliomas and the associated patient care and management, shares her clinical experiences by providing insights into patient selection and referral indications for ¹⁸F-FET PET imaging, with a focus on improving outcomes.

Teaching Points

• Establish one’s foundational understanding of the clinical utility of ¹⁸F-FET PET in neuro-oncology.
• Review of the Response Assessment in Neuro-Oncology Criteria for Gliomas (RANO).
• Discuss the indications for incorporating ¹⁸F-FET PET imaging in the patient’s journey.
• Demonstrate the clinical benefits of ¹⁸F-FET PET for patient with gliomas.
• Compare ¹⁸F-FET PET to current standard of care imaging, supporting its clinical utility.

Note: This module is supported by additional information presented in Reader Training Modules 2, 3 and 4. Test Your Knowledge” competency measurements in the form of quiz questions, will be displayed throughout the module. Upon completion of this Module, a post-test will be offered to provide a Statement of Participation.

Meet the Faculty

Nancy Ann Oberheim Bush, MD, PhD
Wendy Olson Wood-Smith Endowed Professor
Clinical Director, Division of Neuro-Oncology
Department of Neurological Surgery and Neurology
University of California San Francisco

Dr. Oberheim Bush’s experience encompasses treating a range of adult brain tumors, including gliomas, meningiomas, and brain metastases. In addition to clinical care, she is actively involved in clinical research and teaching, with extensive training in clinical trial development, implementation, and analysis.

Dr. Oberheim Bush’s specific research interests include the development of phase I clinical trials testing novel treatment strategies for brain tumor patients. She is currently developing a phase I clinical trial using an engineered viral vector for immunotherapy treatment in patients with recurrent high-grade gliomas. Additional research interests involve the analysis of molecular and imaging markers of resistance to current standard treatment.